Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage
Jingyou Rao, Ruiqi Xin*, Christian Macdonald*, Matthew Howard, Gabriella O. Estevam, Sook Wah Yee, Mingsen Wang, James S. Fraser, Willow Coyote-Maestas†, Harold Pimentel†
Genome Biology,
2024
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics
Sook Wah Yee*, Christian Macdonald*, Darko Mitrovic*, Xujia Zhou, Megan L. Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan Trinidad, Swati S. More, Linda Kachuri, John S. Witte, Lucie Delemotte†, Kathleen M. Giacomini†, Willow Coyote-Maestas†
Molecular Cell,
2024
Molecular basis of proton-sensing by G protein-coupled receptors
Matthew K. Howard*, Nicholas Hoppe*, Xi-Ping Huang, Christian B. Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes, Adam Zahm, Donovan D. Trinidad, Justin English, Willow Coyote-Maestas†, Aashish Manglik†
Biorxiv,
2024
Defining and Reducing Variant Classification Disparities
Moez Dawood†, Shawn Fayer, Sriram Pendyala, Mason Post, Divya Kalra, Karynne Patterson, Eric Venner, Lara A. Muffley, Douglas M. Fowler, Alan F. Rubin, Jennifer E. Posey, Sharon E. Plon, James R. Lupski, Richard A. Gibbs, Lea M. Starita, Carla Daniela Robles-Espinoza, Willow Coyote-Maestas†, Irene Gallego Romero†
Medrxiv,
2024
Profiling the proximal proteome of the activated μ-opioid receptor
Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Prachi Khare, Matthew K. Howard, Alberto J. Gonzalez-Hernandez, Jiewei Xu, Qiongyu Li, Brandon Novy, Zun Zar Chi Naing, Brian K. Shoichet, Willow Coyote-Maestas, Joshua Levitz, Nevan J. Krogan, Mark Von Zastrow† & Ruth Hüttenhain†
Nature Chemical Biology,
2024
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
Estevam GO, Linossi EM, Macdonald CM, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
Biorxiv,
2023
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- Biorxiv Preprint v1: 551866
Deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology
Macdonald CB, Nedrud D, Rockefeller Grimes P, Trinidad D, Fraser JS, Coyote-Maestas W
Genome Biology,
2023
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning
Willow Coyote-Maestas, David Nedrud, Yungui He, Daniel Schmidt
Elife,
2022
Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling
Willow Coyote-Maestas, David Nedrud, Antonio Suma, Yungui He, Kenneth A Matreyek, Douglas M Fowler, Vincenzo Carnevale, Chad L Myers, Daniel Schmidt
Nature communications,
2021
A large‐scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains
David Nedrud, Willow Coyote‐Maestas, Daniel Schmidt
Protein Science,
2021
Targeted insertional mutagenesis libraries for deep domain insertion profiling
Willow Coyote-Maestas*, David Nedrud**, Steffan Okorafor, Yungui He, Daniel Schmidt
Nucleic Acids Research,
2019
Domain insertion permissibility-guided engineering of allostery in ion channels
Willow Coyote-Maestas, Yungui He, Chad L Myers, Daniel Schmidt
Nature communications,
2019
Two distinct pools of B12 analogs reveal community interdependencies in the ocean
Katherine R Heal, Wei Qin, Francois Ribalet, Anthony D Bertagnolli, Willow Coyote-Maestas, Laura R Hmelo, James W Moffett, Allan H Devol, E Virginia Armbrust, David A Stahl, Anitra E Ingalls
PNAS,
2017
