Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage
Jingyou Rao, Ruiqi Xin*, Christian Macdonald*, Matthew Howard, Gabriella O. Estevam, Sook Wah Yee, Mingsen Wang, James S. Fraser, Willow Coyote-Maestas†, Harold Pimentel†
Biorxiv,
2023
Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain
Estevam GO, Linossi EM, Macdonald CM, Espinoza CA, Michaud JM, Coyote-Maestas W, Collisson EA, Jura N, Fraser JS
Biorxiv,
2023
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- Biorxiv Preprint v1: 551866
The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics
Sook Wah Yee*, Christian Macdonald*, Darko Mitrovic*, Xujia Zhou, Megan L. Koleske, Jia Yang, Dina Buitrago Silva, Patrick Rockefeller Grimes, Donovan Trinidad, Swati S. More, Linda Kachuri, John S. Witte, Lucie Delemotte†, Kathleen M. Giacomini†, Willow Coyote-Maestas†
Biorxiv,
2023
Deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology
Macdonald CB, Nedrud D, Rockefeller Grimes P, Trinidad D, Fraser JS, Coyote-Maestas W
Genome Biology,
2023
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning
Willow Coyote-Maestas, David Nedrud, Yungui He, Daniel Schmidt
Elife,
2022
Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling
Willow Coyote-Maestas, David Nedrud, Antonio Suma, Yungui He, Kenneth A Matreyek, Douglas M Fowler, Vincenzo Carnevale, Chad L Myers, Daniel Schmidt
Nature communications,
2021
A large‐scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains
David Nedrud, Willow Coyote‐Maestas, Daniel Schmidt
Protein Science,
2021
Targeted insertional mutagenesis libraries for deep domain insertion profiling
Willow Coyote-Maestas*, David Nedrud**, Steffan Okorafor, Yungui He, Daniel Schmidt
Nucleic Acids Research,
2019
Domain insertion permissibility-guided engineering of allostery in ion channels
Willow Coyote-Maestas, Yungui He, Chad L Myers, Daniel Schmidt
Nature communications,
2019
Two distinct pools of B12 analogs reveal community interdependencies in the ocean
Katherine R Heal, Wei Qin, Francois Ribalet, Anthony D Bertagnolli, Willow Coyote-Maestas, Laura R Hmelo, James W Moffett, Allan H Devol, E Virginia Armbrust, David A Stahl, Anitra E Ingalls
PNAS,
2017
